The α-, β- and γ-catenins are cytoplasmic proteins mediating the interaction of Ca2+-dependent transmembrane adhesion molecules (cadherins) with the cytoskeletal network. The direct interaction of β-catenin with the cytoplasmic domain of cadherins plays a crucial role for cell-cell adhesion and signal transmission between neighboring cells.

Isotype: Mouse IgG1

Clone/PAD: b-Cat-8E4

Immunogen: Peptide containing amino acid residues 27-37, conjugated to KLH.

Specificity: The antibody specifically interacts with nuclear dephosphorylated β-catenin (90 kDa).

Reactivity: Cn, Hu, Ms

Applications: E, ICC, IHC (FFPE), WB

RUO: Research use only