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This purified Rabbit Anti-Histone H3 [pS10] Polyclonal Antibody detects phosphorylated Histone H3. Histone H3 is (17 kDa) is a member of Histone family of proteins (H2A, H2B, H3 & H4) which are the building blocks of chromatin. Histone H3 polyclonal antibody contains 50% glycerol, which improves longevity. Western blotting is a validated application of this Histone H3 polyclonal antibody.
• Applications: Western Blotting is the validated application for rabbit anti-Histone H3 polyclonal antibody. • Host Species: The host species of the Histone H3 antibody is rabbit. • Reactivity: Detects human Histone H3. Mouse and rat (100% homologous) Histone H3 have not been tested, but are expected to react. • Product Size: Histone H3 Polyclonal Antibody is available in a 100 µl pack size. • Immunogen: Phosphopeptide derived from the region of human Histone H3 that contains serine 10.
Histones undergo several post-translational modifications, including acetylation, phosphorylation, methylation and ubiquitination. Histone H3 plays an important role in regulating chromatin organization and hetero-chromatization, which is critical for controlling gene expression and silencing, and represents a potential target for cancer chemotherapy. Histone H3 is phosphorylated on serine 10 by several kinases in the Aurora kinase family. Phosphorylation of Histone H3 is implicated in transcriptional activation, chromosome condensation, and segregation. Phosphorylation of Histone H3 at Ser10 is also essential for EGF-included neoplastic cell transformation.
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