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Rabbit anti-PDGFRα [pY754]; Polyclonal antibody specific to human, rat, and frog. This Antibody is validated in Western blot.Platelet-derived growth factor receptor (PDGFR) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo- or heterodimerization into complexes of α and β subunits upon ligand binding, depending on the isoform of PDGF (PDGF-AA, -BB or -AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras ? Raf ? ERK1&2 pathway. Phosphorylation of tyrosine 754 in the α subunit of the heterodimeric complex is thought to initiate specific signal-transduction pathways distinct from those initiated via homodimeric receptor complexes, as tyrosine 754 has not been shown to be phosphorylated in those complexes. Catalog number 441008G is same antibody as former catalog number 441008. 441008G contains 50% glycerol, which improves the stability and longevity of this antibody.
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