Platelet-derived growth factor receptor (PDGFR) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo- or heterodimerization into complexes of α and β subunits upon ligand binding, depending on the isoform of PDGF (PDGF-AA, -BB or -AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation.

Format:
Unconjugated

Application:
WB

Clone:
Polyclonal

Storage:
FREEZE-20°C

Reference:
Karlsson, S., et al. (2006) Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) beta-receptor but not the PDGF alpha-receptor. Mol. Biol. Cell 17(11):4846-4855. Catalog number 441000G is same antibody as former catalog number 441000. 441000G contains 50% glycerol, which improves the stability and longevity of this antibody.