Mouse anti TNF-α (guinea pig), SKU# 433230, specific to guinea pig . This antibody is validated for use in ELISA. Mouse anti TNF-α (guinea pig) recognizes the expressed product of the TNF-alpha gene, also known as tumor necrosis factor (TNF superfamily, member 2), DADB-70P7.1, DIF, TNF-alpha, TNFA, TNFSF2, APC1 protein, OTTHUMP00000029281, OTTHUMP00000037669, TNF superfamily, member 2, TNF, macrophage-derived, TNF, monocyte-derived, cachectin, tumor necrosis factor alpha.
TNFα (tumor necrosis factor alpha, cachectin) is a cytokine that is secreted mainly by macrophages. Homotrimeric TNFa is glycosylated and this soluble form is derived from the membrane bound form by proteolytic processing. It binds to TNFRSF1A⁄TNFR1 and TNFRSF1B⁄TNFRB and can induce cell death of certain tumor cell lines. Direct action of TNFα or stimulation of interleukin-1 secretion causes fever. Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Genetic variations in TNF are associated with susceptibility to psoriatic arthritis and hepatitis B virus infection.