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Androgen receptor (AR; NR3C4) is a member of the steroid receptor family. The steroid, 5-α- dihydroteststerone can bind to the AR as a ligand. AR is expressed in most tissues and is associated with at least three types of diseases: X-linked androgen insensitivity, spinal/bulbar muscular atrophy and cancer. In presence of its ligand, AR binds as a homodimer to the sequence called ARE (androgen response element). AR has been shown to form heterodimers with glucocorticoid receptors. Two isoforms of AR were identified in human genital skin fibroblasts. The large isoform of 110 kDa (called AR-B) corresponds to the bona fide receptor, whereas the small one of 87 kDa (AR-A) initiate on an internal initiation codon.
Isotype Mouse IgG2a
Immunogen Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human AR (2-53 aa).
Specificity This antibody specifically recognizes human AR and cross reacts with rat AR. Not yet tested in other species.
Reactivity Hu, Rt
Applications Western Blot, ELISA, Immunoprecipitation, Immunohistochemistry (WB, E, IP, IHC)
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