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This purified mouse anti-STRO-1 monoclonal antibody is specific to human STRO-1. Anti-STRO-1 monoclonal antibody recognizes the expressed product of the STRO1 gene. The STRO-1 monoclonal antibody identifies a cell surface antigen expressed by stromal elements in human bone marrow. This Anti-STRO-1 monoclonal antibody is validated for use in flow cytometry and immunocytochemistry.
• Applications: Validated applications for mouse anti-STRO-1 monoclonal antibody are flow cytometry and immunocytochemistry. • Host Species and Isotype: The host species and isotype of the anti-STRO-1 Monoclonal antibody is mouse IgM. • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is Stro-1. • Reactivity: Detects human Stro-1 • Product Size: Mouse anti-STRO-1 monoclonal antibody is available in a 100 µL pack size.
The STRO-1 monoclonal antibody identifies a cell surface antigen expressed by stromal elements in human bone marrow. STRO-1 binds to approximately 10% of bone marrow mononuclear cells, greater than 95% of which are nucleated erythroid precursors, but does not react with committed progenitor cells (colony-forming unit granulocyte-macrophage (CFU-GM), erythroid bursts (BFU-E), and mixed colonies (CFU-Mix). From bone marrow cells, the frequency of fibroblast colonyforming cells (CFU-F) is enriched approximately 100-fold in the STRO-1-positive/Glycophorin A-negative population than in the STRO-1-positive/Glycophorin A-positive population. When plated under long-term BM culture conditions, STRO-1-positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, and fibroblastic elements. A STRO-1-positive enriched subset of marrow cells is capable of differentiating into multiple mesenchymal lineages including hematopoiesis-supportive stromal cells with a vascular smooth muscle-like phenotype, adipocytes, osteoblasts and chondrocytes. STRO-1 is a valuable antibody for the identification, isolation and functional characterization of human bone marrow stromal cell precursors.
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