This purified mouse anti-AID monoclonal antibody is specific to human, mouse, and rat Activation-induced Cytidine Deaminase (AID). This anti-AID monoclonal antibody recognizes the expressed product of the Aicda gene. AID monoclonal antibody can be used in applications such as western blotting, immunohistochemistry, ELISA, immunoprecipitation and immunofluorescence/immunocytochemistry.
• Applications: Validated applications for this anti-AID antibody are western blotting, ELISA, immunohistochemistry, immunoprecipitation, and immunofluorescence.
• Host Species and Isotype: The host species and isotype of the AID antibody is mouse IgG1κ.
• Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is ZA001.
• Reactivity: Detects human AID. Reactivity with mouse and rat is expected based on sequence homology.
• Product Size: AID Monoclonal Antibody is available in a 100 µg pack size.
Activation-induced Cytidine Deaminase (AID or AICDA) is an essential enzyme involved with the regulation of class switch recombination (CSR), somatic hypermutation (SHM), and gene conversion (GC). AID is a member of the RNA-editing deaminase family and may play a role in genetic events in the germinal center B cell. Deficiency of AID in Hyper-IgM syndrome (HIGM2) patients results in the absence of immunoglobulin class switch recombination, lack of immunoglobulin somatic hypermutations, and lymph node hyperplasia, mediated by the presence of giant germinal centers. AID is mainly expressed in lymph nodes and tonsils, and is localized to the cytoplasm, but is observed in the nucleus after DNA damage. AID protein is detected in germinal center centroblast and germinal center-derived lymphomas (Burkitt lymphoma), but not in pre-germinal center B-cells or post-germinal center neoplasms (B-cell chronic lymphocytic leukemia and multiple myeloma).