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This rabbit anti-Claudin-18 (C-Term) polyclonal antibody is specific to mouse, human Claudin-18 (C-term). Claudin-18 (C-Term) polyclonal antibody recognizes the expressed product of the CLDN18 gene also known as Cldn18. Claudin-18 is a tight junction protein expressed as lung- and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene Validated applications for Claudin-18 (C-Term) polyclonal antibody are Western blot, immunohistochemistry and immunofluorescence.
Applications: validated for Western blot, immunohistochemistry and immunofluorescence Host species and isotype: rabbit IgG Polyclonal antibody designation: ZMD.395 Reactivity: mouse and human Claudin-18 (C-term) (based on amino acid sequence homology). Product size: 100 µg pack size
Claudin-18 is a tight junction protein expressed as lung- and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human.1 human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach.1 Claudin-18 expression has also been reported in the inner ear.
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