Monoclonal antibody conjugated to Alexa Fluor® 488, and specific to Human , Rat , Canine and Mouse. This antibody is validated for use in WB, ICC/IF, ELISA and IP. Claudin-1 is encoded by the CLDN7, also known as CLDN7, claudin 7, CEPTRL2, CPETRL2, Hs.84359, claudin-1, Clostridium perfringens enterotoxin receptor-like 2, claudin 9. . The claudin (CLDN) superfamily consists of at least 18 homologous proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport, complexed with two other integral transmembrane proteins, occludin and junctional adhesion molecule.1 Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins interact directly with tight junction-specific, membrane-associated guanylate kinase homologues, ZO-1, ZO-2, and ZO-3, and indirectly with AF-6 and the myosin-binding molecule cingulin. These protein-protein interactions promote scaffolding of the tight junction transmembrane proteins and provide a link to the actin cytoskeleton for transducing regulatory signals to and from tight junctions. Human claudin-1, like other claudin proteins, participates in cell-cell adhesion and regulates paracellular and transcellular transport of solutes across human epithelia and endothelia.2 Recently, a claudin-1 cDNA has been isolated from human mammary epithelial cells (HMECs). As claudin-1 expression is low or undetectable ln a number of breast tumors and breast cancer cell lines, it may be implicated as a possible tumor-suppressor gene.3 1. Heiskala M et al. Traffic 2(2):93-98, 2001. 2. Furuse M et al. J Cell Biol 143(2):391-401, 1998. 3. Kramer F et al. Hum Genet 107:249-256, 2000.