This mouse anti-EphA2 Receptor monoclonal antibody is specific to human, mouse and rat EphA2 Receptor. EphA2 Receptor monoclonal antibody recognizes the expressed product of the EPHA2 gene. EphA2 binds to ephrin-A1, -A3, -A4 and –A5, and is expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung and ovary. Validated applications for EphA2 Receptor monoclonal antibody are immunoprecipitation, Western blotting and ELISA.
Applications: validated for immunoprecipitation, Western blotting and ELISA
Host species and isotype: mouse IgG1-Kappa.
Clone ID of monoclonal antibody (mAb): 1C11A12br>
Reactivity: human, mouse and rat EphA2 Receptor
Product size: 100 µg pack size
The Eph receptors are the largest family of tyrosine kinases. They can be grouped into two subclasses based upon sequence homology: the EphA and EphB receptors. The ligands for the Eph receptors are the ephrins. The EphA receptors bind ephrin-A ligands, which are tethered to the membrane by a GPI linkage, and the EphB receptors bind ephrin-B lignads, which have a membrane spanning region. The Eph receptors are widely expressed during embryonic development, including in the nervous and vascular systems. Ephrins and Eph receptors have been implicated in many developmental processes, including neuronal network formation, guidance of cell migration and axonal pathfinding. They remain expressed at lower levels in adult tissues, and are upregulated in pathological conditions such as cancer.
EphA2 has been previously named Eck, Myk2 and Sek2. It binds to ephrin-A1, -A3, -A4 and –A5, and is expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung and ovary.