This mouse anti-EphB4 Receptor monoclonal antibody is specific to human EphB4 Receptor. EphB4 Receptor monoclonal antibody recognizes the expressed product of the EPHB4 gene. The Eph receptors are widely expressed during embryonic development, including in the nervous system and the vascular system. EphB4 Receptor monoclonal antibodies are the largest family of receptor tyrosine kinases. Validated applications for EphB4 Receptor monoclonal antibody are ELISA, Western blotting, immunohistochemistry and immunoprecipitation.
Applications: validated for Western blot, ELISA and immunocytochemistry and immunoprecipitation
Host species and isotype: mouse IgG1-Kappa
Clone ID of monoclonal antibody (mAb): 3D7G8
Reactivity: human EphB4 Receptor
Product size: 100 µg pack size
The Eph receptors are the largest family of receptor tyrosine kinases. They can be grouped into two subclasses based on sequence homology: the EphA and the EphB receptors4. The ligands for the Eph receptors are the ephrins. The EphA receptors bind ephrin-A ligands, which are tethered to the membrane by a GPI linkage, and the EphB receptors bind ephrin-B ligands, which have a membrane spanning region. The Eph receptors are widely expressed during embryonic development, including in the nervous system and the vascular system. Ephrins and Eph receptors have been implicated in many developmental processes including neuronal network formation, guidance of cell migration, and axonal pathfinding. They remain expressed at lower levels in adult tissues and are upregulated in pathological conditions such as cancer.
EphB4 is expressed in epithelial cells and in endothelial cells of embryonic veins, where its signaling mediates cell migration and proliferation via the PI3K pathway. It is upregulated in several types of tumors, including mammary tumors, colon cancer, and endometrial cancer. EphB4 has previously been designated Htk, Myk1, Tyro11 and Mdk2.