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This mouse anti-EphB2 Receptor monoclonal antibody is specific to chicken EphB2 Receptor and expected to react with human and mouse (not tested). EphB2 is expressed on migrating neural crest cells and spinal motor neurons, as well as on cells of the anterior somite. EphB2 expression and overexpression has been reported in colon carcinomas and gastrointestinal tumor specimens, respectively. Validated applications for EphB2 monoclonal antibody are Western blotting and immunoprecipitation.
Applications: validated for Western blotting and immunoprecipitation Host Species and Isotype: mouse IgG1-Kappa Clone ID of Monoclonal Antibody (mAb): 1A6C9 Reactivity: chicken, (human, mouse) EphB2 receptor Product Size: 100 µg pack size
The Eph receptors are the largest family of receptor tyrosine kinases. They can be grouped into two subclasses based on sequence homology: the EphA and the EphB receptors. The ligands for the Eph receptors are the ephrins. The EphA receptors bind ephrin-A ligands, which are tethered to the membrane by a GPI linkage, and the EphB receptors bind ephrin-B ligands, which have a membrane spanning region. The Eph receptors are widely expressed during embryonic development, including in the nervous system and the vascular system. Ephrins and Eph receptors have been implicated in many developmental processes including neuronal network formation, guidance of cell migration, and axonal pathfinding. They remain expressed at lower levels in adult tissues and are upregulated in pathological conditions such as cancer.
EphB2 is expressed on migrating neural crest cells and spinal motor neurons, as well as on cells of the anterior somite. EphB2 is also expressed in the visual system and in hippocampal neurons. In tumor tissues compared with matched normal tissues, EphB2 expression and overexpression has been reported in colon carcinomas and gastrointestinal tumor specimens, respectively. EphB2 has previously been designated Erk, Hek5 and Drt in human; Nuk and Sek3 in mouse; Cek5 and Qek5 in avian species.
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