This mouse anti-EphA4 receptor monoclonal antibody is specific to human, mouse, and chicken EphA4 receptor. EphA4 Receptor monoclonal antibody recognizes the expressed product of the EPHA4 gene. EphA4 is preferentially expressed in the embryonic and adult nervous system, including the adult hippocampus, and in platelets. Validated applications for EphA4 Receptor monoclonal antibody are ELISA, immunohistochemistry, immunoprecipitation, and Western blotting.
• Applications: Validated applications for EphA4 Receptor monoclonal antibody are ELISA, immunohistochemistry, immunoprecipitation, and Western blotting.
• Host Species and Isotype: The host species and isotype of the EphA4 Receptor monoclonal antibody is mouse IgG1κ.
• Clone ID of Monoclonal Antibody (mAb): The EphA4 Receptor monoclonal antibody clone is 4C8H5.
• Reactivity: EphA4 Receptor monoclonal antibody detects human, mouse, and chicken EphA4.
• Product Size: Mouse anti-EphA4 Receptor monoclonal antibody is available in a 100 µg pack size.
The Eph receptors are the largest family of receptor tyrosine kinases. They can be grouped into two subclasses based on sequence homology: the EphA and the EphB receptors. The ligands for the Eph receptors are the ephrins. The EphA receptors bind ephrin-A ligands, which are tethered to the membrane by a GPI linkage, and the EphB receptors bind ephrin-B ligands, which have a membrane spanning region. The Eph receptors are widely expressed during embryonic development, including in the nervous system and the vascular system. Ephrins and Eph receptors have been implicated in many developmental processes including neuronal network formation, guidance of cell migration, and axonal pathfinding. They remain expressed at lower levels in adult tissues and are upregulated in pathological conditions such as cancer.
EphA4 is preferentially expressed in the embryonic and adult nervous system, including the adult hippocampus, and in platelets. EphA4 has previously been designated Cek8 in chicken, Tyro1 in rat and Sek1 in mouse.