Copy and paste this HTML to embed a link in your website
Paste link in email or IM
This rabbit anti-ERK1+2 [pT202/pY204] polyclonal antibody is specific to human and rat ERK1+2 [pT202/pY204]. ERK1+2 [pT202/pY204] polyclonal antibody recognizes the expressed product of the MAPK1 gene. ERKs are regulated by the binding of extracellular ligands to transmembrane receptors possessing intrinsic or associated tyrosine kinase activity. Validated applications for ERK1+2 [pT202/pY204] polyclonal antibody are Western blot and dot blot.
Applications: validated for are Western blot and dot blot Host species and isotype: rabbit IgG Polyclonal Antibody Designation: PD202 Reactivity: human and rat ERK1+2 [pT202/pY204] Product size: 100 µl pack size
Mitogen activated protein kinase (MAPKs) mediate signal transduction cascades from the cell surface to the nucleus that are responsible for cell growth and differentiation. The activity of MAPK family members is dependent upon dual phosphorylation of threonine and tyrosine residues by an upstream kinase, MKK (or MEK). In mammals, three types of MAPK pathways have been identified: the ERKs (extracellular signal-related protein kinases), JNKs (c-Jun NH2-terminal kinases), and p38 MAP kinases. Activation of a MAPK signaling cascade requires a minimum of three events: the phosphorylation of a MAP kinase kinase kinase (MKKK or MEKK) triggers the phosphorylation of a MAP kinase kinase (MKK or MEK), which in turn phosphorylates the MAP kinase.
ERKs are regulated by the binding of extracellular ligands to transmembrane receptors possessing intrinsic or associated tyrosine kinase activity. At least four distinct ERKs have been identified, including ERK1 (p44), ERK2 (p42), ERK3 (p62), and ERK4 (p45). In humans, activation of MAP kinase (ERK1+ERK2) requires phosphorylation by MEK at Thr202 and Tyr204.
If you continue without changing your settings, we'll assume that you are happy to receive all cookies on Life Technologies websites. However, you can change your cookie settings at any time at the bottom of this page.
To access this page, please close your session and log into the PunchOut session again. You will need to provide an email address on the sign-in page.Please note if you are a punchout to supply center customer, and are viewing this message, your procurement system does not provide the required information to access this tool. Please contact your procurement system administrator for further instructions.