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This purified Rabbit anti-Claudin-4 polyclonal antibody is specific to mouse and rat claudin-4. Anti-Claudin-4 recognizes the expressed product of the Cldn4 gene. Applications that rabbit anti-Claudin-4 polyclonal antibody is validated for use in are Western Blotting, ELISA, Immunoprecipitation, and Immunofluorescence.
• Applications: Validated applications for Rabbit anti-Claudin-4 polyclonal antibody are Western Blotting, ELISA and Immunoprecipitation. Immunofluorescence has also been validated by an outside source. • Host Species and Isotype: The host species and isotype of the anti-Claudin-4 polyclonal antibody is rabbit IgG. • Polyclonal Antibody Designation (PAD): The Claudin-4 polyclonal antibody PAD is ZMD.306. • Reactivity: Reacts with mouse and rat Claudin-4. • Product Size: Rabbit anti-Claudin-4 Polyclonal Antibody is available in a 100 µg size.
Claudin-4 belongs to the 20-member family of claudins; transmembrane proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. The over-expression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl- permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit up regulation at both mRNA and protein levels. Claudin-4 is also over-expressed in pancreatic cancer tissues and cell lines.
Anti-Claudin-4 polyclonal antibody reacts with the mouse Claudin-4. On Western blots a 22 kDa band is observed and a 44 kDa band representing dimerized protein may be observed.
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