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This purified, unconjugated rabbit anti-connexin 36 polyclonal antibody is specific to mouse connexin 36, with expected reaction to human, rat, and zebra fish. This anti-connexin 36 polyclonal antibody recognizes the expressed product of the Gja9 gene, also known as CX36. This rabbit anti-connexin 36 polyclonal antibody is used in western blotting, ELISA, and immunohistochemistry (frozen) applications.
• Applications: Validated applications for polyclonal antibody are western blotting, ELISA, and immunohistochemistry (frozen). • Host Species and Isotype: The host species and isotype of the antibody is rabbit. • Also Known As (pAb): Connexin 36 is also known as CX36, GJA9, GJD2, and RP23-230H3.1. • Reactivity: Reacts with mouse connexin 36. • Product Size: Mouse anti-connexin 36 polyclonal antibody is available in a 100 µg size.
Intercellular communication through gap junctions plays an important role in a variety of cellular processes including homeostasis, morphogenesis, cell differentiation and growth control. Reduction or alteration in the levels or types of connexin expressed in a given cell type has been found to correlate with tumor progression and metastasis.
The murine Cx36 gene encodes a protein of 321 amino acids most homologous to connexin. Based on the presence of an intron within its coding region the Cx36 gene is suggested to form a new delta subclass of murine connexin genes. Specific cell types in the brain express specific types of connexins; expression and expression patterns coincide with tissue compartmentalization and function. These compartments change during development. Cx36 is the first gap junction protein expressed predominantly in neuronal cells of the mammalian central nervous system. It is highly expressed in adult retina and is present in neurons of the inferior olive, the olfactory bulb, the CA3/CA4 hippocampal subfields and several brain-stem nuclei. Cx36 mRNA expression in the brain gradually increases during fetal development until day seven post-partum when its expression begins to decline6. Biophysical measurements of gap junction channels formed by transfected and endogenous Cx36 indicate that they possess unique properties well suited for mediating flexible electrical and biochemical interactions between neurons.
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