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This rabbit anti-Claudin-11/OSP polyclonal antibody is specific to mouse Claudin-11/OSP. Claudin-11/OSP polyclonal antibody recognizes the expressed product of the CLDN11 gene. Oligodendrocyte-specific protein (OSP) is a putative four-transmembrane protein of 22 kDa, which is primarily expressed in oligodendrocytes of the CNS and Sertoli cells of testes in the adult mouse. Validated applications for Claudin-11/OSP polyclonal antibody are Western blotting, ELISA, immunofluorescence and immunoprecipitation.
Applications: validated for Western blotting, ELISA, immunofluorescence and immunoprecipitation Host species and isotype: rabbit IgG Polyclonal Antibody Designation: ZMD.305 Reactivity: mouse Claudin-11/OSP Product size: 100 µg pack size
Oligodendrocyte-specific protein (OSP) is a putative four-transmembrane protein of 22 kDa, which is primarily expressed in oligodendrocytes of the CNS and Sertoli cells of testes in the adult mouse. OSP is the third most abundant CNS myelin protein and contributes to 7% of the total myelin protein. OSP shares sequence homology with the claudin family of tight junction (TJ) proteins, forms TJs in cell culture, co-localizes with structures similar to TJs in myelin, and thus was renamed OSP/Claudin-11. OSP/Claudin-11-null mice lack intramembranous junctions in between Sertoli cells in testes and within CNS myelin sheaths, producing reproductive and neurological deficiencies. This finding indicates that OSP/Claudin-11 is necessary for the formation of TJs.
OSP/Claudin-11 expression is highly regulated during development, suggesting that it may play an important role in growth and differentiation of oligodendrocytes and other cells outside the CNS. OSP/Claudin-11 forms a complex with a novel member of the tetraspanin superfamily (OAP1) and β1 integrin, and regulates proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. Claudin-11 is also expressed in the epithelial tight junctions of the choroids plexus. OSP/Claudin-11 has been implicated as an autoantigen in the development of autoimmune demyelinating disease.
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