This purified rabbit anti-JAM-A polyclonal antibody is specific to human JAM-A. Junctional Adhesion Molecule-A (JAM-A, previously known as JAM-1 in human and mouse) is an integral membrane protein that co-localizes with the tight junction proteins occludin, ZO-1, and cingulin. Validated applications for this rabbit anti-JAM-A polyclonal antibody are immunofluorescence, ELISA and Western blotting.

Antibody Attributes:

• Applications: Validated applications for Rabbit anti-JAM-A polyclonal antibody are immunofluorescence, ELISA and Western blotting.
• Host Species: The host species and isotype of the anti-JAM-A polyclonal antibody is rabbit.
• PAD: The polyclonal antibody PAD is ZMD.275.
• Reactivity: Rabbit anti-JAM-A polyclonal antibody is specific to human JAM-A.
• Product Size: This rabbit anti-JAM-A polyclonal antibody is available in a 100 µg pack size.

Junctional Adhesion Molecule-A (JAM-A, previously known as JAM-1 in human and mouse) is an integral membrane protein that co-localizes with the tight junction proteins occludin, ZO-1, and cingulin. JAM-A has been characterized as a member of the immunoglobulin (Ig) superfamily and is composed of an extracellular domain, a single-pass transmembrane region, and a short cytoplasmic tail. JAM-A is localized at tight junctions in endothelial and epithelial cells and its sub-cellular distribution is modulated by inflammatory cytokines. JAM-A is also expressed on circulating leukocytes and platelets, as well as in lymphoid. Most claudins as well as JAM-A end with the amino acid Val at their C-terminal ends, suggesting that these C-termini bind directly to PDZ domains.

JAM-A appears to be a single copy gene, constitutively expressed on various tissues and cells, and whose product may be involved in cell-cell adhesion through homophilic interactions. JAM-A has been detected in human intestine cell lines T84, CaCo2 and HT29, in the lung cell line A 549, and the liver cell line HepG2.