This purified, unconjugated rabbit anti-claudin-7 polyclonal antibody is specific to human, mouse and chicken claudin-7. Anti-claudin-7 polyclonal antibody recognizes the expressed product of the CLDN7 gene. Claudin-7 is localized in the intercellular junctions of the epithelial cells of the proximal tubules of the nephrons in mammalian kidney. Rabbit anti-claudin-7 polyclonal antibody has been validated for use in western blotting, immunofluorescence, and immunohistochemistry (FFPE) applications.

Antibody Specifications:

• Applications: Validated applications for Rabbit anti-Claudin-7 polyclonal antibody are western blotting, immunofluorescence, and immunohistochemistry (FFPE).
• Host Species: The host species of the anti-Claudin-7 polyclonal antibody is rabbit.
• Immunogen: Synthetic peptide derived from the C-terminal region of the human claudin-7 protein.
• Reactivity: Reacts with human, canine and mouse claudin-7.
• Product Size: Rabbit anti-claudin-7 polyclonal antibody is available in a 100 µg size.

Tight junctions are specialized regions of cell-cell contact that are particularly abundant in luminal epithelial cell sheets. In freeze-fracture electron micrographs, tight junctions are visualized as belt-like bands of anastomosing sealing strands (TJ strands) that completely encircle the lateral surfaces of each cell. TJ strands on adjacent cells are presumed to interact with each other to form a sort of "molecular gasket" that prevents ions, water and other molecules from leaking between cells and thus, from one side of the sheet to the other. In addition to this so-called "barrier" function, the "fence" function of tight junctions plays an important role in maintaining epithelial cell-polarity by blocking the diffusion of membrane proteins between apical (luminal) and baso-lateral cell surfaces. Claudin-7 is localized in the intercellular junctions of the epithelial cells of the proximal tubules of the nephrons in mammalian kidney. It is reportedly down regulated in head and neck squamous cell carcinomas. Claudin-7 is also expressed in normal human and mouse epithelia.