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This purified E-Cadherin Monoclonal Antibody is specific to human E-Cadherin. The expression of E-cadherin correlates inversely with the motile and invasive behavior of tumor cells. Mouse anti- E-Cadherin monoclonal antibody can be used in applications such as western blotting, immunohistochemistry, immunocytochemistry/immunofluorescence, and immunoprecipitation. This anti- E-Cadherin monoclonal antibody recognizes the product of the CDH1 gene.
• Applications: Validated applications for this E-Cadherin antibody are western blotting, immunohistochemistry, and immunoprecipitation. • Host Species and Isotype: The host species and isotype of this E-Cadherin antibody is mouse IgG1κ • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 4A2C7. • Reactivity: Detects human E-Cadherin • Product Size: E-Cadherin Monoclonal Antibody is available in a 100 µg pack size.
Cadherins are a multifunctional family of Ca2+-dependent, transmembrane glycoproteins that promote and maintain cell adhesion in virtually all multicellular organisms. The cadherin superfamily comprises over forty proteins that share, on average, 50-60% homology. Cadherin expression is required for the assembly of cells into solid tissues, and occurs in a tissue-specific fashion. Homotypic cellular interactions are promoted by homophillic interactions between the extracellular regions of like cadherin molecules on neighboring cells. Recent crystal structure analysis of an extracellular cadherin domain suggests that individual cadherin molecules cooperate to form a linear cell adhesion zipper. In adherens junctions, cadherins are anchored to the actin cytoskeleton by interaction with the small cytoplasmic proteins β-catenin and γ-catenin which both bind to the actin-binding protein α-catenin. The interaction of β-catenin with the cytoplasmic tail of cadherins and other cytoplasmic proteins, including Tcf-family transcription factors and the tumor suppressor protein APC, is thought to be mediated through a region of the β-catenin molecule containing multiple repeats of the 42 amino acid armadillo sequence motif. In addition to playing important roles in differentiation and tissue morphogenesis, cadherins also appear to play a significant role in modulating tumor invasion and metastasis. The expression of E-cadherin correlates inversely with the motile and invasive behavior of tumor cells. In addition, the tissue specificity of cadherin subtypes is becoming a valuable marker for the identification and differential diagnosis of certain cancers.
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