This mouse anti-desmoglein-2 monoclonal antibody is specific to human desmoglein-2. Anti-desmoglein-2 monoclonal antibody recognizes the expressed product of the DSG2 gene. The expression of desmoglein-2 varies in the basal layers, depending on the certain types of epidermis. Validated applications for this desmoglein-2 monoclonal antibody are immunoprecipitation, immunostaining, and Western blotting.

Antibody Attributes:

• Applications: Validated applications for this desmoglein-2 monoclonal antibody are Western blotting, immunostaining, and immunoprecipitation.
• Host Species and Isotype: The host species and isotype of the desmoglein-2 monoclonal antibody is mouse IgG1.
• Clone ID of Monoclonal Antibody (mAb): This desmoglein-2 monoclonal antibody clone is 6D8.
• Reactivity: Desmoglein-2 monoclonal antibody detects human desmoglein-2.
• Product Size: Desmoglein-2 monoclonal antibody is available in a 100 µg pack size.

Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion.

Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein1-3 and desmocollin1-3. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmoglein-1 is synthesized exclusively in the suprabasal layers. The expression of desmoglein-2 varies in the basal layers, depending on the certain types of epidermis. And desmoglein-3 is expressed in both the basal and the lower suprabasal compartments.

Domain specific desmosomal and adherens junction-associated antibodies have been widely used in recent studies. In one study, domain specific antibodies were used to determine the cellular localization of the skin of patients with Hailey-Hailey disease and Darier's disease. Desmosomal cadherin antibodies are also useful for targeting specific disease and in the study of interaction between cell adhesion proteins.