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Mouse Anti-β-Tubulin Monoclonal Antibody is specific to Human, Mouse, Rat, and Nematode β-Tubulin. Validated applications for Mouse Anti-β-Tubulin Monoclonal Antibody are Immunofluorescence and Western Blot. Mouse Anti-β-Tubulin Monoclonal Antibody recognizes the expressed product of the TUBB2A gene, also known as TULP1, TUBB3, TUBB4, TUBB2C, TUBE1, TUBB1 and TUBB.
• Applications: Validated applications for Mouse Anti-β-Tubulin Monoclonal Antibody are Western blotting and immunofluorescence. • Host Species and Isotype: The host species and isotype is mouse IgG1κ. • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 2-28-33. • Reactivity: Reactivity is confirmed with human, mouse, and rat β-tubulin. • Product Size: Mouse Anti-β-Tubulin Monoclonal Antibody is available in a 100 µg pack size.
The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use. The effects on tubulin messenger-RNA levels and tubulin protein synthesis of microtubule-depolymerizing drugs or the direct microinjection of cells with tubulin suggest that non-polymerized tubulin depresses its own synthesis.
Accumulation of tubulin protein and an increased array of microtubules have been associated with contractile dysfunction in cardiac myocytes after pressure overload in vivo. Studies have also shown that cardiac activity can increase the amount of β-tubulin in rat cardiac myocytes. Tubulin production in cultured cardiac myocytes can be regulated directly by mechanical forces. In mechanically challenged hearts, the accumulation of β-tubulin and the development of contractile dysfunction may be directly related to the mechanical forces imposed on the myocardium during the onset and progression of cardiovascular disease. This antibody reacts with ~50 kDa β-tubulin and has been shown to bind to the two major and one of the minor β-tubulin isotypes.
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