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Mouse anti-α-Tubulin Monoclonal Antibody conjugated to AlexaFluor® 488 is specific to human, Mouse, and Rat α-Tubulin. Validated applications for use with Mouse anti-α-Tubulin Monoclonal Antibody are Immunofluorescence and Western Blot. Mouse Anti-α-Tubulin Monoclonal Antibody recognizes the expressed product of the TUBA1 gene.
• Applications: Validated applications for Mouse anti-alpha-Tubulin AlexaFluor® 488 Monoclonal Antibody are western blotting and immunofluorescence. Reactivity is confirmed with NIH3T3 cells, rat brain, mouse testis, human Caco-2, HeLa3 and PtK23 cells. • Host Species and Isotype: The host species and isotype is mouse IgG1κ. • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is B-5-1-2. • Reactivity: Reactivity is confirmed with human, mouse, and rat α-tubulin. • Product Size: Mouse Anti-α-Tubulin AlexaFluor® 488 Monoclonal Antibody is available in a 100 µg pack size.
The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use. The effects on tubulin messenger RNA levels and tubulin protein synthesis of microtubule-depolymerizing drugs and of direct microinjection of cells with tubulin suggest that non-polymerized tubulin represses its own synthesis.
There are three classes of the ~50 kDa tubulin proteins: alpha, beta, and gamma. The alpha and beta tubulins form a heterodimer that polymerize into the cylindrical microtubule fibers. Both alpha and beta tubulin bind GTP; however, only beta tubulin hydrolyzes GTP to GDP. This hydrolysis is a process that is linked to tubulin polymerization and microtubule formation. The alpha tubulin isoform can be modified by the addition of a C-terminal tyrosine residue, and this modification may influence polymerization rates. The gamma tubulin isoform is localized to centrosomes which compose the heart of the microtubule organizing center from which microtubule fibers emanate.
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