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Full Product Description This monoclonal antibody is specific for MSH6. Inherited (germline) mutations in DNA mismatch repair genes such as MLH1, MSH2, MSH3, and MSH6 are the major cause of hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. A characteristic of HNPCC tumors is microsatellite instability (MSI). Detection of microsatellite instability in a tumor sample will increase the probability of detecting a germline mutation in a DNA mismatch repair gene from the patient sample. Thus, MSI analysis is usually performed prior to proceeding with full mutation analysis of mismatch repair genes. Immunohistochemical (IHC) analysis of suspected HNPCC tumor samples has come into favor as a means of screening patients who may carry a mutation or a deletion in one of the mismatch repair (MMR) genes. Positive tissue: Colon carcinoma
Immunogen Recombinant protein corresponding to the N-terminus of human MSH6
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