This purified mouse anti-transferrin receptor monoclonal antibody recognizes the transferrin receptor. The human transferrin receptor (TfR) is a homodimeric type II membrane protein consisting of two identical 95 kDa subunits covalently linked by intermolecular disulfide bonds. An important function of the transferrin receptor is to bind the serum transport protein transferrin (Tf) and mediate the uptake of iron into the cell. This mouse anti-transferrin receptor monoclonal antibody is validated for use in western blot, immunoprecipitation, immunohistochemistry, ELISA, and immunofluorescence.

Antibody Specifications:

• Applications: Validated applications for this transferrin receptor antibody are western blotting, ELISA, immunohistochemistry, immunoprecipitation, and immunofluorescence.
• Host Species and Isotype: The host species and isotype of this transferrin receptor antibody is mouse IgG1.
• Clone ID of Monoclonal Antibody (mAb): This anti-TR monoclonal antibody clone is H68.4.
• Reactivity: Detects human E-Cadherin. Cross reactivity is observed with chicken, mouse, rat and Chinese hamster transferrin receptor due to conserved amino acid sequences in the cytoplasmic tail.
• Product Size: Mouse anti-transferrin receptor monoclonal antibody is available in a 500 µg pack size.

The human transferrin receptor (TR) is a homodimeric type II membrane protein consisting of two identical 95 kDa subunits covalently linked by intermolecular disulfide bonds. The TR has an extracellular domain of 671 amino acids, a single 28 residue transmembrane region and a 61 residue amino terminal cytoplasmic domain. Expression of the receptor is limited on normal tissue, however, highly expressed on the surface of some tumors. TR is included in the class of ligand transport receptors which are internalized and clustered in coated pits. An important function of the receptor is to bind the serum transport protein transferrin (TF) and mediate the uptake of iron into the cell. A growing area of research involves the use of monoclonal anti-TF receptor antibodies to inhibit the uptake of iron and thus block tumor cell growth.